炎症に関与する化学的因子の研究 : 第1篇炎症巣におけるリウコタキシンの遊離に関する研究

概要

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Leukotaxin extracted from pleural exudates of rabbits and dogs by the Menkin's method has studied chemically and biologically. 1) The active principle of leukotaxin corresponded to polypeptide I by paper partition chromatography and biological examinations. 2) Polypeptide I was detectalble by the chlorine-iodide-starch procedure (Rydon & Smith method) though the Rf value was relatively variable, and it was negative to ninhydrin reaction and disappeared by acid hydrolysis. The hydrolysate of the substance contained at least six ninhydrin positive substances. 3) Pleural exudates contain several free amino acids beside polypeptide I mentioned above. The species of animals and degree of inflammation had no influence on the constituents of the free amino acids in the pleural exudates. 4) Beside polypeptide I, several factors of fraction C-D extracted by the Menkin's method were found by paper partition chromatography in the area of lower Rf value of the chromatograms, and they had the biological activities of causing dilatation of vessels and edema of tissues.
一般社団法人日本アレルギー学会の論文
1961-04-30