気管支喘息小児にたいする Intal (disodium cromoglycate) の効果

概要

論文の詳細を見る
Inhibitory effects of chemical mediator liberation following an antigen-antibody reaction were reported on inhaled Intal. To investigate further efficacy on this drug on children in asthma, influences on 1) provocative inhalation with extract of house dust, 2) on airway histamine hypersensitivity, 3) on daily pulmonary function, were studied. Pretreatment by the inhalation of the Intal resulted in complete inhibition of asthmatic reaction to bronchial provocative test with H.D. in 2 cases and also resulted in significant elevation of H.D. threshhold in 6 of 7 cases. Elevation of histamine threshhold over 25% to control value was found in about 60% of 29 pretreated tests with the Intal. Two of influenced cases showed no meaningful reduction in PEFR measurements even after the inhaltion of 500 γ of aerosole histamine. In four times daily PEFR measurement statistically significant improvemant in pulmonary function produced by 3 times daily Intal inhalation was found in 60% of 13 trials, which was consisted of 5 days of Intal administration and every 5 days for control both before and after Intal period. These observations indicate that the Intal not only interfers with the liberation of chemical mediators following an antigen-antibody reaction but also reduces itself the airway histamine hypersensitivity and bronchospasm characteristic to asthmatic patents.
日本アレルギー学会の論文
1969-08-30