ジフテリア症に於ける陰性期の意義に関する実験的研究 : II陰性期と感染の関係

概要

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Experiment was planned to see whether or not the diphtheric infection develops during the course of"negative Phase"caused by the toxoid injection to the actively immunized guinea pigs. The antitoxin level necessary to prevent the conjunctival infection was about 0.003 unit per ml in the actively immunized guinea pigs, while animals having the antitoxin more than 0.1-0.3 unit proved to be susceptible to infection by virulent diphtheria bacilli for a while after they had received a large amount of toxoid (250 Lf per animal). However, the results do not necessarily lead to the critical opinion against the present tendency to immunized population during epidemics, since the amount usually used in the prophylaxis is very small when compared with that necessary to lower the resistance of the animals significantly. Moreover, the beneficial effect of the toxoid injection during epidemics might be supported by the fact that the rapid reproduction of the antitoxin after the negative phase may serve to prevent the clinical manifestations of the diphtheria infection in human beings.
一般社団法人日本アレルギー学会の論文
1960-09-01