ジフテリア症に於ける陰性期の意義に関する実験的研究 : I陰性期とシック反応の関係

概要

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A number of guinea pigs previously immunized with diphtheria toxoid received each a second dose of the toxoid subcutaneously, and changes in the circulating antitoxin and the neutralization power of the skin were followed. The latter was determined by the quantitative Schick test (QST). The circulating antitoxin decreased soon after the second injection and reached the minimum value after 24 hours. The neutralizing power of the skin also decreased as the circulating antitoxin fell. However, the linear relationships were always recognized between the neutralizing power of the skin and the amount of circulating antitoxin observed just before the QST. Statistical analysis suggested that the relative value of the neutralization power of the skin to the circulating antitoxin ("neutralization index") seemed to be similar during 48 hours after the second dose of toxoid, while the significant decrease of"neutralization index"was observed after 72 hours. Another groups of similarly immunized guinea pigs received the QST at first and then they were injected with the second dose of toxoid at various time interval, and the effect of the latter on the results of QST was followed. The second dose given simultaneously or shortly after the QST (-e.g. 2 hours) seemed to lower the neutralization power of the skin significantly, but no effect was observed when it was given 16 hours after the QST.
一般社団法人日本アレルギー学会の論文
1960-09-01