ヘモリジンによる生体反応に関する研究 : 第1報 皮膚に於ける血管内性抗原抗体反応について
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The macroscopic and microscopic studies were carried out on the skin reaction in the guinea pig produced by the intracutaneous injection of the anti-guinea-pig red-cell rabbit-serum (titer 64 ×). From the findings of the macroscopic observation, both edema and hyperemia in the skin tissues were observed, accompanying the hemorrhage. From four to six hours after the injection the skin reaction was not remarkable. Microscopically, the hemorrhage was found conspicuously all over the cutis of the local skin tissue. The dilatation of the veins, thrombosis and ruptures of its wall was observed. The infiltrations of the polymorphnucleal leucocytes, however, was not found remarkably at the hemorrhagic region. All those reactions are apparently the typical intravascular antigen-antibody reactions pathologically. By injecting the hemolysate developed from the blood which has been dissolved by adding the hemolysin in the test tube, the skin reaction was observed to be developed. As the microscopic findings of the skin tissues a subcutaneous hemorrhage in small scale, a slight destruction of the wall of small veins on the part of subcutaneous tissue, and the stases of blood circulation were observed. In comparision with the first group, the reaction seemed to be slight in general. A similar experiment was performed by using the hemolysin removed aggulutinin, but the skin reaction were markedly restrained. From the results obtained throughout the present experiments it might be said that the aggulutinin has acted almost in the similar attitude to the hemolysin.
- 日本アレルギー学会の論文
- 1960-04-01
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