アレルギー性皮膚反応の定量的研究

概要

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The amount of antigen and antibody required for the development of Arthus reaction was studied in guinea pigs using ovalbumin-antiovalbumin system. After the provocative injections of the antigen intradermally to the sensitized guinea pigs, the amounts of antigen as well as antibody in the local sites were persued using these reagents labelled with ^<131>I. The antigen/antibody ratio in the sites was estimated from these results. The antibody concentration in the site increased immediately after the injections of the antigen, while, a part of the antigen injected disappeared from the site, combining with antibody in the circulation and in the tissues. The development of the Arthus reaction was closely related to the amount of antibody in the site present at 4 hours after the antigen injection, when hemorrage appears in positive reactions, but was irrespective of either the amount of tissue antibody before the antigen injection or the antigen/antibody ratio in the sites immediately after the injection. When the hemorrage appeared, the amount of antibody in the reactive sites was more than 1.2 μg N and the antigen/antibody ratio in these sites was either in equivalence or in the region of excess antigen. These findings suggested the possibility that the Arthus reaction might be induced when the total amounts of antigen and antibody reacted in the site reached to a certain extent.
日本アレルギー学会の論文
1960-03-01