臨床アレルギーにおける抗原輸送体としての白血球 : 第1報主として焦点巣疾患々者の白血球について

概要

論文の詳細を見る
The immunological roles of leukocyte in the clinical allergy, especially bacterial one, were investigated, using the skin reaction as an index which followed the intracutaneous injection of leukocytes. Granulocytes and lymphocytes were seperated from the peripheral blood sample chiefly by means of sedimentation and centrifugation. The leukocytes thus obtained were crushed with the sonic vibration and injected intracutaneously. The leukocytes obtained from patients with various focal infections were injected to patients with various diseases and to normal subjects. Positive skin reactions were observed in patients with rheumatic endocarditis, rheumatic valvular diseases, rheumatoid arthritis, chronic glomerulonephritis, neurocirculatory asthenia, "abdominal neurosis", lupus erythematodes, food allergy, aplastic anemia, and pulmonary tuberculosis. In most of these diseases it appears that there exist allergic reactions caused by the hemolytic streptococcal infections and this probably played an important role in their pathogenesis. Positive skin reactions were generally observed more frequently in cases of lymphocyte injection than in cases of granulocyte injection. It is suggested that leukocytes, especially lymphocytes, have property to combine themselves with the bacteria (chiefly hemolytic streptococci) or antigenic bacterial substances and serve for the transportation of the latter.
一般社団法人日本アレルギー学会の論文
1960-12-01