セルラーオートマトン法を用いた生体骨の適応的再構築に関する研究(<特集>材料の内部構造と力学特性)

概要

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In this paper, the adaptive bone remodeling is simulated by using the cellular automata (CA) method. It is assumed that each cell has a property of Bone marrow, Osteoclast, Osteoblast, Bone cell or Osteoprogenitor cell. Two types of local rule are adopted, that are the metabolism rule and adaptive bone formation rule. The metabolism rule is based on the interactions of cells and the bone formation rule is based on the adaptation against the mechanical stimulus. The history of load and memory of mechanical stimulus are also considered in the local rules. As the simulation model, two dimensional femur model is considered and the adaptive remodeling of the cancellous bone is simulated. As the result, the pattern of distribution of the bone tissue is dynamically adequate and it can be regarded as the trabecula. It is shown that the CA method is one of the simulation method to express the adaptive bone remodeling.
社団法人日本機械学会の論文
2002-11-25