Cytogenetic Analysis of Thymocytes during Early Stages after Irradiation in Mice with Different Susceptibilities to Radiation-Induced Lymphomagenesis

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概要

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• To investigate the relationship between radiation-induced chromosomal instability and lymphomagenesis, the incidences of chromosome aberrations and of cells with abnormal chromosome complements in the thymuses of B 10Thy 1.1 and STS/A strains which have shown marked differences in susceptibility to radiation-induced lymphomagenesis were compared at an early time (12-33 days) after whole-body X-irradiation (1.61Gy X 4). Numerical and structural aberrations of chromosome in B 10Thy 1.1 mice were higher than those in STS/A mice. The average incidence of trisomy 15 was 37.5% (12/32 mice) from 12 days to 32 days after irradiation in B10. Thy 1.1 mice, whereas none was found (0/38 mice) in STS/A mice. Frequencies of aberrations in chromosomes 11, 12, 15 of the thymocytes from irradiated B lOThy 1.1 mice were higher than those from irradiated STS/A mice, and especially, the most frequent translocations occurred in the E-F regions of chromosome 12. Using B lO.Thy I congenic mice, we found that in many cases (8/13), the chromosome aberrations detected in the thymocytes from B I O.Thy I , I mice at an early time after irradiation could also be observed in the donor-type (Thy 1.1 ) lymphomas developed from recipient mice 4-5 months after intrathymic injection, suggesting that these chromosome aberrations have some role in lymphomagenesis. The difference of chromosome instability detected at an early time after irradiation might be due to genetic background with regard to genomic instability induced by radiation.

• 日本放射線影響学会の論文

著者

• KUBO Eiko

  Div. Biol. Oncol.

• Muto Masahiro

  Div. Biol. Oncol.

• Muto M

  Nat. Inst. Radiol. Sci.

• Chen Ying

  Department of Endocrinology, First Hospital of China Medical University

• Kubo Eiko

  Nat. Inst. Radiol. Sci.

• Kubo Eiko

  放射線医学総合研究所

• Kubo Eiko

  Division Of Physiology And Pathology National Institute Of Radiological Sciences

• Muto Masahiro

  京都大学 理学研究科

• Muto Masahiro

  Division Of Physiology And Pathology National Institute Of Radiological Sciences

• Sado T

  Div. Biol. Oncol. Natl. Inst. Radiol. Sci.

• Sado Toshihiko

  Division Of Physiology And Pathology National Institute Of Radiological Sciences

• Sado Toshihiko

  Division Of Physiology And Pathology National Institute Of Radiological Science

• Muto Masahiro

  Division Of Biology And Oncology

• Muto Masahiro

  Division Of Oncology And Biology National Institute Of Radiological Sciences

• Kubo E

  Nat. Inst. Radiol. Sci.

• Kubo Eiko

  Division Of Biology And Oncology

• Ying Chen

  Dep. Radiobiology China Inst. Rad. Pro.

• Sado Toshihiko

  Div. Clin. Res. Radiat. Health. Natl Inst. Radiat. Sci.

• Chen Y

  Tohoku Univ.

• Chen Y

  Tohoku University

• Chen Ying

  Department Of Anatomy The First Medical University Of Pla

• CHEN Ying

  Japan Science and Technology Corporation (JST)

• Chen Ying

  Tohoku University

• CHEN Ying

  Department of Anatomy , The First Medical University of PLA

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