RNA secondary structure and compensatory evolution
スポンサーリンク
概要
- 論文の詳細を見る
The classic concept of epistatic fitness interactions between genes has been extended to study interactions within gene regions, especially between nucleotides that are important in maintaining pre-mRNA/mRNA secondary structures. It is shown that the majority of linkage disequilibria found within the Drosophila Adh gene are likely to be caused by epistatic selection operating on RNA secondary structures. A recently proposed method of RNA secondary structure prediction based on DNA sequence comparisons is reviewed and applied to several types of RNAs, including tRNA, rRNA, and mRNA. The patterns of covariation in these RNAs are analyzed based on Kimuras compensatory evolution model. The results suggest that this model describes the substitution process in the pairing regions (helices) of RNA secondary structures well when the helices are evolutionarily conserved and thermodynamically stable, but fails in some other cases. Epistatic selection maintaining pre-mRNA/mRNA secondary structures is compared to weak selective forces that determine features such as base composition and synonymous codon usage. The relationships among these forces and their relative strengths are addressed. Finally, our mutagenesis experiments using the Drosophila Adh locus are reviewed. These experiments analyze long-range compensatory interactions between the 5 and 3 ends of Adh mRNA, the different constraints on secondary structures in introns and exons, and the possible role of secondary structures in RNA splicing.
- 日本遺伝学会の論文
- 1999-12-01
著者
-
Chen Ying
Department of Endocrinology, First Hospital of China Medical University
-
Baines John
Department Of Biology University Of Rochester Rochester
-
Carlini David
Department Of Biology University Of Rochester Rochester
-
Chen Ying
Department Of Anatomy The First Medical University Of Pla
-
Tanda S
Department Of Biology University Of Maryland
-
PARSCH John
Department of Biology, University of Rochester, Rochester
-
BRAVERMAN John
Department of Biology, University of Rochester, Rochester
-
TANDA Soichi
Department of Biology, University of Maryland
-
STEPHAN Wolfgang
Department of Biology, University of Rochester, Rochester
-
Stephan Wolfgang
Department Of Biology University Of Rochester Rochester
-
Braverman John
Department Of Biology University Of Rochester Rochester
-
Parsch John
Department Of Biology University Of Rochester Rochester
-
Chen Ying
Department Of Biology University Of Rochester Rochester
-
CHEN Ying
Department of Anatomy , The First Medical University of PLA
関連論文
- Ghrelin Modulates Insulin Sensitivity and Tau Phosphorylation in High Glucose-Induced Hippocampal Neurons
- Development of a Solid Supersaturatable Self-Emulsifying Drug Delivery System of Docetaxel with Improved Dissolution and Bioavailability
- Self-Microemulsifying Drug Delivery System (SMEDDS) of Vinpocetine : Formulation Development and in Vivo Assessment(Miscellaneous)
- IGF-1 as an early marker for low bone mass or osteoporosis in premenopausal and postmenopausal women
- Cytogenetic Analysis of Thymocytes during Early Stages after Irradiation in Mice with Different Susceptibilities to Radiation-Induced Lymphomagenesis
- 3D analysis of the spinning behavior of flossy cocoon mutants in the silkworm, Bombyx mori
- Cytokine alteration and speculated immunological pathophysiology in silicosis and asbestos-related diseases
- The biological effects of negatively-charged indoor air conditions
- Is soluble CD40 ligand an indicator of immunopathological disturbance in silicosis patients?
- Effects of reducing dietary crude protein on growth performance, odor gas emission from manure and blood urea nitrogen and IGF-1 concentrations of serum in nursery pigs
- First-Principles Calculation of L1_0-Disorder Phase Boundary in Fe-Pd System
- First-Principles Calculation of Point Defects in Uranium Dioxide
- RNA secondary structure and compensatory evolution
- 合成オリゴタクレオチドをプロ-ブとしたキイロショウジョウバエG6PD遺伝子のクロ-ニング〔英文〕
- キイロショウジョウバエのG6PD活性を調節する染色体外因子(速報)〔英文〕
- キイロショウジョウバエのG6PD活性調節遺伝子〔英文〕
- キイロショウジョウバエX連鎖酵素活性を支配する調節遺伝子系〔英文〕
- High-performance liquid chromatography/tandem mass spectrometry method for the simultaneous determination of cytarabine and its valyl prodrug valcytarabine in rat plasma
- Identification and characterization of human autophagy 5β, a human autophagy 5 isoform(THE SIXTH JAPAN-CHINA JOINT SEMINAR ON HISTOCHEMISTRY AND CYTOCHEMISTRY)