Clustered DNA Damages Induced in Human Hematopoietic Cells by Low Doses of Ionizing Radiation

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概要

• 論文の詳細を見る

• Ionizing radiation induces clusters of DNA damages - oxidized bases, abasic sites and strand breaks - on opposing strands within a few helical turns. Such damages have been postulated to be difficult to repair, as are double strand breaks (one type of cluster). We have shown that low doses of low and high linear energy transfer (LET) radiation induce such damage clusters in human cells. In human cells, DSB are about 30% of the total of complex damages, and the levels of DSBs and oxidized pyrimidine clusters are similar. The dose responses for cluster induction in cells can be described by a linear relationship, implying that even low doses of ionizing radiation can produce clustered damages. Studies are in progress to determine whether clusters can be produced by mechanisms other than ionizing radiation, as well as the levels of various cluster types formed by low and high LET radiation.

• 日本放射線影響学会の論文

著者

• Trunk John

  Biology Department Brookhaven National Laboratory

• Sutherland Betsy

  Biology Department Brookhaven National Laboratory

• Hada M

  Department Of Biology Faculty Of Science Kobe University

• Hada Megumi

  Biology Department Brookhaven National Laboratory

• BENNETT PAULA

  Biology Department, Brookhaven National Laboratory

• CINTRON-TORRES NELA

  Biology Department, Brookhaven National Laboratory

• MONTELEONE DENISE

  Biology Department, Brookhaven National Laboratory

• SUTHERLAND JOHN

  Biology Department, Brookhaven National Laboratory

• LAVAL JACQUES

  Groupe Reparation de l'ADN

• STANISLAUS MARISHA

  Department of Medicine, School of Medicine, University of Pennsylvania

• GEWIRTZ ALAN

  Department of Medicine, School of Medicine, University of Pennsylvania

• Sutherland John

  Biology Department Brookhaven National Laboratory:physics Department East Carolina University

• Monteleone Denise

  Biology Department Brookhaven National Laboratory

• Stanislaus Marisha

  Department Of Medicine School Of Medicine University Of Pennsylvania

• Cintron-torres Nela

  Biology Department Brookhaven National Laboratory

• Bennett Paula

  Biology Department Brookhaven National Laboratory

• Gewirtz Alan

  Department Of Medicine School Of Medicine University Of Pennsylvania

• Laval Jacques

  Groupe Reparation De L'adn

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• Clustered DNA Damages Induced in Human Hematopoietic Cells by Low Doses of Ionizing Radiation

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