Radiosensitization by Bromodeoxyuridine and Hyperthermia: Analysis of Linear and Quadratic Parameters of Radiation Survival Curves of Two Human Tumor Cell Lines

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概要

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• Sensitization by bromodeoxyuridine (BrdUrd) and hyperthermia (HT) on cell reproductive death induced by ionizing radiation was analyzed using the linear-quadratic [S(D)/S(0)=exp{-( αD+ βD^2 )}] model. Plateau-phase human lung tumor cells (SW-1573) and human colorectal carcinonoma cells (RKO) were treated with BrdUrd, radiation and HT. LQ-analysis was performed at iso-incubation dose and at iso-incorporation level of BrdUrd, and at iso-HT doses and iso-survival levels after HT. Clonogenic assays were performed 24 h after treatment to allow repair of potentially lethal damage (PLD). In SW cells BrdUrd, HT or the combination significantly increased the α-parameter (factor 2.0- 5.7), without altering the β-parameter. In RKO cells sensitization with BrdUrd increased both α (factor 1.4) and β(factor 1.3) while HT only influenced β (factor 2.1-4.0). The combination did not further increase the α and β The results indicate that BrdUrd has its main effect on the parameter α, dominant at clinically relevant radiation doses but that HT can affect both α and β The addition of BrdUrd and HT provides a method to enhance the efficacy of radiotherapy.

• 日本放射線影響学会の論文

著者

• Barendsen Gerrit

  オランダ

• Barendsen Gerrit

  Department Of Radiotherapy Academic Medical Center University Of Amsterdam

• FRANKEN NICOLAAS

  Department of Radiotherapy, Academic Medical Center, University of Amsterdam

• BREE CHRIS

  Department of Radiotherapy, Academic Medical Center, University of Amsterdam

• VELTMAAT MARTIJN

  Department of Radiotherapy, Academic Medical Center, University of Amsterdam

• RODERMOND HANS

  Department of Radiotherapy, Academic Medical Center, University of Amsterdam

• HAVEMAN JAAP

  Department of Radiotherapy, Academic Medical Center, University of Amsterdam

• Van Bree

  Department Of Radiotherapy Academic Medical Center University Of Amsterdam

• Bree Chris

  Academic Medical Center University Of Amsterdam Laboratory For Experimental Oncology And Radiobiolog

• Haveman J

  Academic Medical Center University Of Amsterdam Laboratory For Experimental Oncology And Radiobiolog

• Haveman Jaap

  Department Of Radiotherapy Academic Medical Center University Of Amsterdam

• Rodermond H

  Univ. Amsterdam Amsterdam Nld

• Franken Nicolaas

  Academic Medical Center University Of Amsterdam Laboratory For Experimental Oncology And Radiobiolog

• Franken Nicolaas

  Department Of Radiotherapy Academic Medical Center University Of Amsterdam

• Veltmaat Martijn

  Department Of Radiotherapy Academic Medical Center University Of Amsterdam

• Rodermond Hans

  Department Of Radiotherapy Academic Medical Center University Of Amsterdam

関連論文

• Radiosensitization by Bromodeoxyuridine and Hyperthermia: Analysis of Linear and Quadratic Parameters of Radiation Survival Curves of Two Human Tumor Cell Lines
• Residual Late Radiation Damage in Mouse Stromal Tissue Assessed by the Tumor Bed Effect
• Chromosome Fragments have the Potential to Predict Hyperthermia-induced Radio-sensitization in Two Different Human Tumor Cell Lines
• Effects of Gemcitabine on Cell Survival and Chromosome Aberrations after Pulsed Low Dose-rate Irradiation

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