Analysis of Relative Biological Effectiveness of High Energy Heavy Ions in Comparison to Experimental Data
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概要
- 論文の詳細を見る
We report that the relative biological effectiveness (RBE) of accelerated heavy ions for inactivation of cells can be analyzed by using the quadratic dependence on the linear energy transfer (LET) of the cellular effect. For high-LET radiation in low-dose regions, the inactivation cross section (σ) can be approximately expressed asσ_<max> [1-exp [-k・(LET/L_1 )^2 ]; here, k is the number of heavy-ions traversed in a cell nucleus and L_1 is a geometrical parameter related to the DNA structure, which depends on cell type. This original expression was first presented by Powers et al [Int. J. Radiat. Biol. 14 (1968)]. Using this expression and the Poisson distribution for the stochastic property of particle hitting, the mortality of cell populations was calculated. The numerical results were compared to the RBE values recently obtained with Chinese hamster V79 cells, and an L_1 value of 152 keV/μm was found to give the best fit. At LETs of between 30 and 500 keV/μm, the D_<10> values (10% survival dose) agreed with the experimental data within an error range of -15%〜+8%.
- 日本放射線影響学会の論文
著者
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SOGA Fuminori
Division of Accelerator Physics and Engineering
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SATO Yukio
Division of Internal Medicine II, Fukushima Medical University School of Medicine
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Sato Y
College Of Technology Toyama Prefectural University
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Sato Yukio
College Of Technology Toyama Prefectural University
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Sato Yukio
Division Of Accelerator Physics And Engineering National Institute Of Radiological Sciences
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Soga F
Divisin Of Accelerator Physics And Engineering National Institite Of Radiological Sciences Chiba Jap
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Soga Fuminori
Natl. Inst. Radiol. Sci. :chiba Univ.
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