Skin and Bone Tumors Induced by Repeated Beta-Irradiation of Mice: Threshold Effect and p53 Mutations

概要

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The question as to whether a threshold dose exists in radiation carcinogenesis is important for the estimation of radiation risk at low doses. Although the relationship between the radiation dose and tumor incidence fits a multihit or linear-quadratic model, a threshold model can not be excluded. In fact, the radiation dose at which no increase in tumor incidence is recognized over the background level can be seen in the induction of solid tumors and leukemia with single whole body exposure to X-rays or gamma rays, as well as in pulmonary tumors caused by partial irradiation with single doses of up to 2.5 Gy of X rays in mice. When irradiation is protracted or the total dose fractionated, no apparent increases in tumor incidence in skin cancer in mice and rats occurs, or in ovarian tumor and leukemia in mice. Error-free repair of DNA damaged by a low dose, low dose rate, or fractionated exposure is considered to be efficient.
日本放射線影響学会の論文