2-Mercaptopropionyiglycine Affords Enhanced Radioprotection After a Liposome Encapsulation

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概要

• 論文の詳細を見る

• Use of radioprotective drugs in radiotherapy is desirable to protect normal tissues. 2-mercaptopropionyiglycine (MPG) has shown promising results in experimental radioprotection. In this report, a liposome drug delivery system for MPG has been used in Swiss albino mice exposed to 1 to 8 Gy whole body Gamma-irradiation to test whether or not this modality enhances the MPG afforded radio-protection. A statistically significant, dose dependent enhancement of protection by liposome encapsulated MPG (LEM) was observed. LEM, as compared to free MPG, improved the viabilities of spleen and bone marrow cells by factors between 1.11 and 2.23 for different doses of radiation.

• 日本放射線影響学会の論文

著者

• Srivastava P

  Nuclear Science Center Jnu Campus

• Sharan R

  Radiation &molecular Biology Unit Department Of Biochemistry School Of Life Sciences North-easte

• Sharan R.n.

  Radiation &molecular Biology Unit Department Of Biochemistry North-eastern Hill University

• Saikia Jyoti

  Radiation &molecular Biology Unit Department Of Biochemistry School Of Life Sciences North-easte

• ALAM A.

  lmmunology Laboratory, Department of Biochemistry, School of Life Sciences North-Eastern Hill Univer

• CHAKRABORTY SANGHAMITRA

  Radiation &Molecular Biology Unit, Department of Biochemistry, School of Life Sciences North-Eastern

• SRIVASTAVA P.N.

  Nuclear Science Center, JNU Campus

• Chakraborty Sanghamitra

  Radiation &molecular Biology Unit Department Of Biochemistry School Of Life Sciences North-easte

• Alam A.

  Lmmunology Laboratory Department Of Biochemistry School Of Life Sciences North-eastern Hill Universi

関連論文

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• 2-Mercaptopropionyiglycine Affords Enhanced Radioprotection After a Liposome Encapsulation
• Effect of the Radioprotector 2-Mercaptopropionyiglycine (MPG) on the Radiation Inactivation of Catalase In Vitro
• ^7Li Particles Induced Plasmid DNA Damages Is Influenced by Nucleotide Sequence

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