Radioprotection by 16,16 Dimethyl Prostaglandin E_2 is Equally Effective in Male and Female Mice

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概要

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• Pretreatment with 16, 16 dimethyl prostaglandin E_2 (DiPGE_2) provides effective protection against radiation and chemical injury. Cytoprotection against chemical injury is known to be influenced by sex factors, and is more effective in females than males. Since prostaglandin metabolism and biological responses to prostaglandin may vary between sexes, studies were conducted to compare DiPGE2-induced radioprotection in male and female mice. Pretreatment with 400 μg DiPGE_2/ kg body wt substantially enhanced 30-day survival in males and females. There was no significant difference in the LD^<50/30> of male and female mice receiving vehicle alone prior to irradiation, 8.34 Gy versus 8.46 Gy, respectively. DiPGE_2 treatment increased the LD^<50/30> in males to 12.1 Gy, providing a dose modification factor (DMF) of 1.45. Similar increases were observed in females, with a LD^<50/30> of 11.6 and a DMF of 1.37. The reported difference in DiPGE_2-induced cytoprotection between males and females exposed to ethanol injury, and the lack of variation in the present radioprotection study suggests that separate mechanisms are involved in the two processes.

著者

• Walden Jr.

  Radiation Biochemistry Department Armed Forces Radiobiology Research Institute: (present Addresse) D

• FARZANEH NUSHIN

  Radiation Biochemistry Department, Armed Forces Radiobiology Research Institute

• Farzaneh Nushin

  Radiation Biochemistry Department Armed Forces Radiobiology Research Institute: (present Addresse) D

関連論文

• Radioprotection by 16,16 Dimethyl Prostaglandin E_2 is Equally Effective in Male and Female Mice
• Radioprotection of Mouse Hematopoictic Stem Cells by Leukotriene A4 and Lipoxin B4

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