Radioprotection of Mouse Hematopoictic Stem Cells by Leukotriene A4 and Lipoxin B4

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概要

• 論文の詳細を見る

• The potent cyto/radioprotective biological activity induced by leukotrienes prompted a search for other lipoxygenase products exhibiting similar properties. Pretreatment of mice with 1 to 20 , μg of leukotriene A_4 before sublethal irradiation induced an increase in the number of endogenous hematopoietic stem cells. Radioprotection was also provided by pretreatment with lipoxin B_4, but not with lipoxin A_4 or with potential lipoxin precursors:5-HETE, 15-HPETE, 15-HETE, and arachidonic acid. The degree of protection induced by leukotriene A_4 or lipoxin B_4 is less than that previously reported for an equivalent dose of leukotriene C_4. Administration of the lipoxins did not result in any visibly detectable side effects such as diarrhea or ataxia.

• 日本放射線影響学会の論文

著者

• Walden Jr.

  Radiation Biochemistry Department Armed Forces Radiobiology Research Institute: (present Addresse) D

• Walden Jr.

  Radiation Biochemistry Dept. Armed Forces Radiobiology Research Institute

関連論文

• Radioprotection by 16,16 Dimethyl Prostaglandin E_2 is Equally Effective in Male and Female Mice
• Radioprotection of Mouse Hematopoictic Stem Cells by Leukotriene A4 and Lipoxin B4

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