Persistent Chromosome Aberrations in the Somatic Cells of A-bomb Survivors, Hiroshima and Nagasaki : II. BIOLOGICAL EFFECTS

スポンサーリンク

概要

• 論文の詳細を見る

• Current status of knowledge on the radiation-induced chromosome aberrations persisting since their induction in 1945 to date in the somatic cells of A-bomb survivors in Hiroshima and Nagasaki is reviewed. Dose-response relationship for chromosome aberration frequencies observed with the use of the old A-bomb dosimetry system (T65D) is also demonstrable based on the new dosimetry system (DS86). Despite the fact that the remarkable decrease in the amount of neutron component relative to the total dose in Hiroshima, there still exist inter-city differences in aberration frequency per unit dose both for kerma and bone marrow dose; the dose-square term is smaller in Hiroshima than in Nagasaki. The differential contribution of neutron radiation may be responsible in some part for the observed difference between Hiroshima and Nagasaki, although proof still remains to be obtained. There is a wide variability of the frequency of cells with chromosome aberrations between survivors within a given dose range. Random errors in the dose estimates assigned to individual survivors seem responsible, to a large extent, for the observed overdispersions in aberration frequencies in both cities. New molecular biology-oriented techniques to differentially stain specific chromosomes using fluorescence in situ hybridization with chromosome-specific composite DNA probes seem extremely promising for future rapid, accurate and extensive screening of reciprocal translocations observed predominantly in A-bomb survivors. Such data may be utilized to establish a better biological dosimetry system, especially for those persons who are irradiated in vivo many years before cytogenetic examinations.

• 日本放射線影響学会の論文

著者

• Awa Akio

  Dept. Genet. Radiation Effects Research Foundation Hiroshima

• Awa A

  Radiation Effects Research Foundation Hiroshima Jpn

• Awa Akio

  Department Of Generics

• Awa A.

  Dept. Of Genetics Rerf

• AWA AKIO

  Cytogenetics Laboratory, Department of Genetics, Radiation Effects Research Foundation

• Awa Akio

  Genetics Radiation Effects Research Foundation

関連論文

• O-17. Is there evidence for genetic instabilities in lymphocytes of A-bomb survivors? : chromosome analysis of clonally expanded T-cell populations by M-FISH method(Abstracts of the oral and poster presentations,Abstracts of the 55th Annual Meeting of the
• O-16. Radiation-induced translocations in T cells of Hiroshima A-bomb survivors(Abstracts of the oral and poster presentations,Abstracts of the 55th Annual Meeting of the Society of Chromosome Research)
• 55 Chromosome Aberrations, Clone Formation, and Leukemia(Chromosome aberrations, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Random Location of Human Chromosomes in Interphase Nuclei
• Chromosome aberration : Inv(14)(q11q32) in lymphocytes from Hiroshima A-bomb survivors
• Fingerprint of High LET radiation (F-value) for chromosome aberration and radiation effects of atomic bomb.
• Translocation breakpoints distribute less frequently in chromosome terminal portion in lymphocytes of A-bomb survivors
• Why Cancer Risks in A-Bomb Survivors Levels Off above 2 Sv?
• Frequencies of Stable Chromosome Aberrations in Atomic Bomb Survivors-New Insights of Dose ResponseCurves by Shielding Categories
• T-lymphocyte Stem Cell Structure Deduced from Clonal Chromosome Aberrations
• DOES THE CHROMOSOME ABERRATION DOSE RESPONSE VARY DEPENDING ON THE DIRECTION FROM THE HYPOCENTER?
• Identification of clonal chromosome aberrations by repeated lymphocyte tests in A-bomb survivors.
• Clustering of interstitial deletions on chromosome 5q in the lymphocytes from atomic-bomb survivors.
• Dose-response relationship for frequencies of stable chromosome aberrations in A-bomb survivors - Variation in dose-response curves by shielding categories.
• Estimation of minimum length of translocated chromosome tips detectable by FISH.
• Comparison of iranslocation frequencies between FISH and conventional methods in lymphocytes from A-bomb survivors.
• Analysis on translocation frequencies in Hiroshima A-bomb survivors by fluorescence in suu hybridization.
• Factors that Determine the in vivo Dose-Response Relationship for Stable Chromosome Aberrations in A-Bomb Survivors
• Persistent Chromosome Aberrations in the Somatic Cells of A-bomb Survivors, Hiroshima and Nagasaki : II. BIOLOGICAL EFFECTS

もっと見る 閉じる

スポンサーリンク