Difference in the Lethal Effects of Carcinogens/Mutagens among Three Cultured Goldfish (Carassius auratus) Cell Lines

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概要

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• The sensitivities of three goldfish-cell lines to the lethal effects of four carcinogens/mutagens; 4-nitroquinoline-1-oxide (4NQO), 1-methyl-3-nitro-1-nitrosoguanidine (MNNG), mitomycin C (MMC) and bleomycin (BLM), were compared using colony-formation assay. RBCF-1 and CAF-MM1 cells were more sensitive to 4NQO, BLM and UV than were GEM 199 cells. CAF-MM1 and GEM 199 cells showed almost the same sensitivity to MNNG, while the RBCF-1 cells were more sensitive. RBCF-l cells were also the most sensitive to MMC and BLM among the three. This suggests that there may be some defect in DNA repair system in RBCF-1 cell line.

• 日本放射線影響学会の論文

著者

• Mitani Hiroshi

  Zoological Institute Faculty Of Science The University Of Tokyo

関連論文

• Eurythermic Growth and Synthesis of Heat Shock Proteins of Primary Cultured Goldfish Cells : Cell Biology and Morphology
• Radiosensitivity of Primary Cultured Fish Cells with Different Ploidy
• Difference in the Lethal Effects of Carcinogens/Mutagens among Three Cultured Goldfish (Carassius auratus) Cell Lines

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