Alteration in Radiation-Induced Change in K^+ Permeability of Mouse Fibroblast LM Cells by Modification of Their Membranes with Unsaturated Fatty Acids

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概要

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• The membrane lipid of murine fibroblast LM cells, which can grow in serum-free medium, was modified by adding an unsaturated fatty acid (palmitoleate, oleate, linoleate or linolenate) to the medium. After irradiation with ^<60>Co γ-rays at 0℃ or 25℃, these cells lost their intracellular K^+ with time, and the degree of loss varied depending on the modification of their membranes:palmitoleate-supplemented membranes were most resistant to radiation, whereas linolenate-supplemented ones were least resistant at 4℃ and 25℃. No membrane constituents other than lipids seemed to be appreciably modified, judging from the indirect evidence that the rates of 42K incorporation into linolenate-supplemented and -unsupplemented cells at 37℃ were the same. Thus, these differences in the damage indicate that membrane lipids take part in the radiation-induced change in K^+ permeability of LM cells.

• 日本放射線影響学会の論文

著者

• 土井 脩

  国立予防衛生研究所

• 鈴木 捷三

  東京大学医科学研究所

• 赤松 穰

  国立予防衛生研究所

関連論文

• Alteration in Radiation-Induced Change in K^+ Permeability of Mouse Fibroblast LM Cells by Modification of Their Membranes with Unsaturated Fatty Acids
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• 高等動物細胞膜リン脂質の代謝と機能に関する遺伝生化学的研究

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