The Oxygen Effects of X-Rays and Neutrons on the Membrane Permeability of Sheep Erythrocytes

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概要

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• In order to clarify the sites in a cell which were susceptible to oxygen effect by radiation, its effect on the membrane permeability of sheep erythrocytes was investigated with 200 kVp X-rays and 6 MeV cyclotron neutrons in the presence and absence of oxygen. Radiation damage to membranes, irradiated at room temperature and stored for 20 hours at 4°and 37℃, was assessed from both the escape of K^+ from the cells and the incorporation of Na^+ into the cells. The values of OER (oxygen enhancement ratio) and RBE (relative biological effectivenss) for the damage by neutrons at 4°C were 1.0 and 3.1, respectively. The same value of OER was obtained by X-rays. No oxygen effect was also observed even at 37℃ where the repair of damage to membranes existed. These results are incompatible with the model that membranes are sites of type 'O' damage susceptible to oxygen effect. It is well known that the presence of oxygen during irradiation increases damage to cells, but its mechanism is not well understood. Alper has proposed the model for radiation damage to cells that in a cell there are two sites of damage;one site, referred to as type 'O' damage, has a high oxygen enhancement ratio, the other site, referred to as type 'N' damage, has a low oxygen enhancement ratio.

• 日本放射線影響学会の論文

著者

• 鈴木 捷三

  東京大学医科学研究所

関連論文

• Alteration in Radiation-Induced Change in K^+ Permeability of Mouse Fibroblast LM Cells by Modification of Their Membranes with Unsaturated Fatty Acids
• Radiation-Induced Ouabain-Insensitive K+ Exchange of Erythrocytes under the Quasi-Physiological Conditions
• Radioresistance of the Liposomal Membrane Permeability
• The Oxygen Effects of X-Rays and Neutrons on the Membrane Permeability of Sheep Erythrocytes

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