Effect of 2-Mercaptopropionyiglycine and 2-Aminoethyl Isothiuronium Bromide Hydrobromide on Leucocytes in Peripheral Blood After Gamma Ray Exposure in Mice

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2-Mercaptopropionyl glycine (MPG) treatment has not improved leucocytopenia in laboratory mice after 760R or 1060R gamma exposure inspite of the fact that reduction in the total leucocyte count was slightly less in MPG treated group on the 10th day after 760R gamma exposure; leucocytopenia was more marked in MPG treated group on the 14th day and 21st day after 760R gamma exposure as compared to that in control animals. Two hundred mg/kg of 2-aminoethyl isothiuronium bromide hydrobromide (AET) treatment which is half the recommended dose for radioprotection has offered considerable protection to leucopenia after 760R and 1060R gamma exposure. It has also helped substantially in rapid recovery of lymphocytes after 760R exposure. MPG combined with two hundred mg/kg AET has not offered any extra radioprotection to peripheral blood leucocytes after 760R gamma exposure, on the contrary the combination has been less effective than the respective AET dose given singly. Similar result has been noted with combination treatment of MPG and 40 mg/kg AET in 1060R gamma exposure.
日本放射線影響学会の論文