The Effect of Normal Ovarian Tissue on the Ovarian Tumorigenesis in X-Irradiated Mice
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The ovarian tumors induced by X-ray irradiation were histologically examined in ddY/F and C3H/TW strains of mice 15 months after irradiation. Luteomas were developed predominantly in ddY/F mice after whole-body irradiation and tubular adenomas in C3H/TW mice. However, when one ovary was shielded from irradiation in ddY/F mice, no ovarian tumors were found in any of the irradiated contralateral ovaries. After the removal of the normal ovary at 1 or 6 months after irradiation, the increase in the incidence of tubular adenomas and the decrease of the luteomas were resulted in ddY/F mice when examined at 15 months after irradiation. No tumors were induced in the ovaries which were grafted subcutaneously after the X-ray irradiation of the recipient. These results suggested that hormonal conditions especially during early stages of tumorigenesis may determine the type of ovarian tumors. It is generally accepted that the hormonal imbalance is among the important factors for the ovarian tumorigenesis in mice and rats after X-ray irradiation, exposure to chemical carcinogens or surgical manipulations. Hypophysectomy or administration of estrogen completely inhibited the occurrence of ovarian tumors in mice exposed to DMBA or X-rays, although administration of androgen was ineffective. The presence of a normal ovary also totally abolished the development of tumors in the mouse ovary exposed to X-rays or DMBA. The present experiments were intended to study whether the inhibitory effect of the presence of a normal ovary on the ovarian tumorigenesis was reversible.
- 日本放射線影響学会の論文
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関連論文
- The Effect of Normal Ovarian Tissue on the Ovarian Tumorigenesis in X-Irradiated Mice
- Ovarian Tumorigenesis after Whole Body X-Ray lrradiation in ddY/F and C3H/TW Mice
- マウスにおける卵巣腫瘍の形成(形態学)