Ovarian Tumorigenesis after Whole Body X-Ray lrradiation in ddY/F and C3H/TW Mice

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The process of ovarian tumorigenesis in ddY/F and C3H/TW mice was studied at various times until 18 months after whole body irradiation with a single dose of 130R or 260 R of X-rays. The first ovarian tumors were observed at 9 months after irradiation in ddY/F mice. In a total of 28 of 71 ddY/F mice, 33 ovarian tumors were developed, which were subdivided to 25 luteomas, 4 granulosa-cell tumors, one mixed cell tumor and 3 tubular adenomas. On the other hand, 21 of 29 C3H/TW mice had altogether 32 tubular adenomas and one mixed cell tumor. At older ages, small interstitial cells with eosinophilic cytoplasm were observed in irradiated ovaries. The cells resembled luteoma cells. Luteoma may be derived from the small interstitial cells. Since the earlier works by Parkes, Brambell et al. , it has been well documented that mammalian ovaries are very sensitive to radiation in all stages of postnatal life. Furth and Furth, Upton et al. reported that ovarian tumors developed in mice at more than 7-10 months after irradiation at 5-12 weeks of age.
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