Gamma-Irradiation of Cytosine ^<14>C-2 Labelled DNA of Eschedchia coli Identification of the Major Radiolysis Products Resulting from Rupture of the N-Glycosidic Bond
スポンサーリンク
概要
- 論文の詳細を見る
The radiolysis products resulting from the cleavage of the N-glycosidic linkage after gamma irradiation of cytosine ^<14>C-2 labelled DNA of Escherichia coli were mainly cytosine and trans 5,6-dihydroxy-5,6 dihydro uracil. Relative percentages of these products were determined against doses and mechanism of release suggested. For a long time, deoxyribonucleic acid has been recognized as the principal target of ionizing radiations in living cells. Comprehensive approaches towards molecular events concerning this biopolymer have been achieved taking advantage of the knowledge of radiolytic decomposition of nucleic acid components in aqueous solution. Studies on radiolysis of the components of DNA must be performed prior to the radiolysis of macromolecular DNA, because the radiolysis products from DNA are formed only very little so that their nature should be identified by comparison with the authentic substances which have been found in studies on components.
- 日本放射線影響学会の論文
著者
-
Teoule R.
Laboratoire De Radiobiochimie Departement De Recherche Fondamentale Centre D'etudes Nucleaires
-
Teoule R.
Laboratoire De Radiobiotogie Department De Recherche Fondamentale Centre D'etudes Nucleaires De
-
POLVERELLI M.
Laboratoire de Radiobiotogie, Department de Recherche Fondamentale, Centre d'Etudes Nucleaires de Gr
-
BONICEL A.
Laboratoire de Radiobiotogie, Department de Recherche Fondamentale, Centre d'Etudes Nucleaires de Gr
-
Bonicel A.
Laboratoire De Radiobiochimie Departement De Recherche Fondamentale Centre D'etudes Nucleaires
-
Bonicel A.
Laboratoire De Radiobiotogie Department De Recherche Fondamentale Centre D'etudes Nucleaires De
-
Polverelli M.
Laboratoire De Radiobiotogie Department De Recherche Fondamentale Centre D'etudes Nucleaires De Grenoble
関連論文
- Gamma-Irradiation of Cytosine ^C-2 Labelled DNA of Eschedchia coli Identification of the Major Radiolysis Products Resulting from Rupture of the N-Glycosidic Bond
- N-Formamido Group Formed in the Place of Thymine Fragment under Gamma lrradiation of DNA. Rapid Indirect Mcthod of Evaluation both in vitro and in vivo Conditions