N^6-Substituted Adenosine Derivatives : Radioprotection, Whole Body Distribution, and Their Effects on Blood Pressure and Respiration Rates.
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概要
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Six derivatives of adenosine were examined on their pharmacological actions and whole body distribution in relation to their radioprotective action. They all caused a large drop in blood pressure and slowdown of pulse rate in rats. Respiration rate was slightly decreased with concomitant overbreathing. Labeled compounds of two of these adenosine derivatives, N-(<SUP>14</SUP>C-2-hydroxyethyl) adenosine and N-(<SUP>35</SUP>S-2-mercaptoethyl) adenosine, were synthesized. Whole body autoradiographic study in mice showed a significant accumulation of the compounds in liver, spleen, intestinal mucosa, and bone marrow.
- 日本放射線影響学会の論文
日本放射線影響学会 | 論文
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