Modification of Radiosensitivity of Ehrlich Ascites Carcinoma Cells in vivo. Part 1, Some Basic Experiments on the Role of Lethally Irradiated Tumor Cells

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Some basic experiments were performed on our animal-tumor system of Ehrlich ascites carcinoma cells in ddYF mice. All the results are presented in terms of TD_<50> or the number of cells which transplant tumor in half of the recipients. The animals responded to active immunization and to whole body irradiation with 400 rads with an increase and a decrease of TD_<50> respectively. It is of interest that TD_<50> correlated negatively with the number of lethally irradiated tumor cells (LR cells) when viable cells were transplanted together with LR cells. The TD_<50> fell as the number of LR cells increased and it finally seems to approach to one viable cell. A method of drawing x-ray survival curves of tumor cells without using LR cells is discussed, and an example is given which indicate that our Ehrlich ascites tumor cells irradiated under hypoxic conditions "in vitro" or "in situ" have a radiosensitivity of m = 2 and D_0 = 390 rads.
日本放射線影響学会の論文