Electron Microscopic Study on Adrenal Medullary Cells of Rats following Whole Body X-irradiation

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Electron microscopic study on adrenal medullary cells of rats after whole body X-irradiation was made. Adult male rats of the Donryu strain, weighing 150-170 g, were irradiated with X-ray (700 R. ), and the rats showing a lowering of blood pressure were killed at 72 hours after irradiation. Two types of medullary cells, active and degenerated type, were observed in the irradiated rats. The degenerated cells were more numerous than the active cells, and the former showed mitochondrial swelling, dilated cystic rough-surfaced endoplasmic reticulum and abundant ribosomes. There was found almost complete depletion of catecholamine granules. On the contrary, the active cells had numerous ribosomes, abundant rough-surfaced endoplasmic reticulum, many vacuoles, and exhibited a moderate decrease in number of catecholamine granules. These results suggest that an exhausted condition of medullary cells appeared after hyperfunction due to sympathetic stimulation following whole body X-irradiation and the relationship between lowering blood pressure and degeneration of medullary cells was correlative.
日本放射線影響学会の論文