A Study on the Relationship between Blood Pressure and Chromaffine Cells of the Adrenal Medulla after X-ray Irradiation

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The present studies were undertaken to investigate the relationship between blood pressure and adrenal medullary cells (norepinephrinecontaining cells) in adult male rats after whole body X-ray irradiation (700 R. ). 1. Both systolic and diastolic values of blood pressure elevated at 3, 24 and 48 hours after irradiation, but systolic pressure became lower than the normal level at 0.5 and 72 hours (p<0.01). 2. Pulse rate decreased at 3, 72 and 120 hours after irradiation (p<0.01). Although pulse rate showed tendency to decrease in 24 and 48 hours, it was not statistically significant. 3. Increase in number of norepinephrine-containing cells with marked accumulation of cytoplasmic granules was seen at 3, 12, 24 and 48 hours after irradiation (p<0.01). On the other hand, decrease in number of cytoplasmic granules associated with marked degeneration was observed at 72 and 120 hours. 4. These results indicated the positive correlation between blood pressure and morphological changes of norepinephrine-containing cells.
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