噴霧熱分解法によりアルミナセラミックス上に形成させた多孔質β-リン酸三カルシウム膜のキャラクタリゼーション及び骨芽細胞を用いたin vitro評価

概要

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Porous calcium-phosphate films were formed on alumina ceramics by a spray-pyrolysis technique, using two kinds of starting solutions having Ca/P ratios of 0.50 and 1.67. A β-tricalcium phosphate (β-TCP) phase was present in the resulting films with a thickness of about 50μm. The films were porous and the median pore size was about 105μm. After Scotch^[○!R] tape (#810) adhering to the films was removed from the substrates, the films were still present on the substrate. The biocompatibility of the alumina ceramics coated with β-TCP (simply referred to as coated specimen) was examined using MC3T3-E1 cells as an osteoblast model. The cells on the coated specimen well proliferated in a similar manner to those cultured polystyrene dish and on uncoated alumina ceramics. The alkaline phosphatase activity of the cells cultured on the coated specimen for 17 d was significantly higher than that of the uncoated alumina ceramics. The present porous β-TCP films have good cellular responses with respect to cell proliferation and differentiation.
社団法人日本セラミックス協会の論文
2005-03-01