神経節細胞腫

概要

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A 16-year-old boy, with a more than 4-year history of partial seizure, was found to have a well-circumscribed subcortical tumor mass in the left parietal lobe. The tumor, which was partially cystic, was totally removed and a histological examination using light and electron microscopes was consistent with gangliocytoma. There was neither evidence of malignancy, nor recurrence of the tumor over a follow-up period of more than 3 years. Sixty-eight cases of ganglion cell tumors including the present case were collected from the literature. The tumors belonged to a rather hamartomatous entity, occurred most frequently in ear-ly childhood and adolescence, and showed a slight preponderance in males. The average duration of the symptoms was 2 years 7 months. No specific tumor symptoms or signs were encountered, and these were mostly dependent on the size or location of the growth. Increased intracranial pressure was observed in 62% of the cases, whereas 70% of the cases showed some localized neurological signs and 40% were accompanied by seizures. The tumors occurred more frequently in the cerebral hemisphere, especially in the temporal lobe. Multicentric tumor occurrence was extremely rare. In general, the prognosis was favorable and the best outcome was observed in cases of total resection. Only eight cases showed recurrence and radiation therapy appeared ineffective.
日本脳神経外科学会の論文
1984-04-15