Distinctive Pleomorphic Xanthoastrocytoma-Like Tumor With Exclusive Abortive or Aberrant Neuronal Differentiation and Repeated Recurrence
スポンサーリンク
概要
- 論文の詳細を見る
A 9-year-old girl with a 1-month history of generalized seizure presented with a distinctive tumor resembling pleomorphic xanthoastrocytoma. Neuroimagings showed a right frontotemporal lobe tumor. Histological examination of the resected tumor indicated similarity to pleomorphic xanthoastrocytoma without staining for glial fibrillary acidic protein. The neuronal immunoreactivity and ultrastructural features showed two discrepancies: Numerous cytoplasmic processes containing rich structures suspected to be microtubules and neurofilaments were present, but neurofilament protein 70 kd/200 kd staining was negative; and many tumor cells showed synaptophysin staining, but no synaptic structures or vesicles were observed. She suffered recurrence 14 months after the first surgery. The specimen from the second operation revealed no malignant transformation with a MIB-1 labeling index of 1.9%. Only 2 months after the second operation, there was a second recurrence. Irradiation was administered (60.2 Gy). Twenty-eight months later, no tumor progression was seen. This tumor was an unconventional type with "abortive" or "aberrant" neuronal differentiation or an extreme variant of pleomorphic xantboastrocytoma.
- 日本脳神経外科学会の論文
- 2002-09-15
著者
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Okada Motoi
Department of Emergency Medicine, Asahikawa Medical College
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Okada Motoi
Department Of Cardiology Asahikawa Medical College
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Okada Motoi
Departments Of Pathology Koshigaya Municipal Hospital
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TSUNODA Akira
Department of Surgery, School of Medicine, Showa University
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EBATO Michimasa
Departments of Neurosurgery, Koshigaya Municipal Hospital
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MARUKI Chikashi
Departments of Neurosurgery, Koshigaya Municipal Hospital
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IKEYA Furitsu
Departments of Neurosurgery, Koshigaya Municipal Hospital
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Ikeya Furitsu
Department Of Neurosurgery Juntendo University School Of Medicine
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Ikeya Furitsu
Departments Of Neurosurgery Koshigaya Municipal Hospital
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Tsunoda Akira
Departments Of Neurosurgery Koshigaya Municipal Hospital
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Tsunoda Akira
Department Of Gastroenterological And General Surgery Showa University School Of Medicine
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Ebato Michimasa
Departments Of Neurosurgery Koshigaya Municipal Hospital
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Maruki Chikashi
Departments Of Neurosurgery Koshigaya Municipal Hospital
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Maruki Chikashi
Department Of Neurosurgery Juntendo University School Of Medicine
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