Cerebral Amyloid Angiopathy Associated With Hemorrhage : Immunohistochemical Study of 41 Biopsy Cases
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概要
- 論文の詳細を見る
The relationship between cerebral amyloid angiopathy and hemorrhage was investigated by an immunohistochemical study of biopsy cases to characterize the involvement of amyloid β-protein, apolipoprotein E, and cystatin C in cerebral amyloid angiopathy associated with hemorrhage. The amyloid-laden vessels were examined in biopsy specimens from 41 surgical cases of sporadic cerebral amyloid angiopathy (36 cases with hemorrhage and 5 cases without hemorrhage), using immunohistochemical staining with antibodies against amyloid β-protein, apolipoprotein E, cystatin C, and α-smooth muscle actin. The relationship between the occurrence, recurrence, and enlargement of the hemorrhage, and the semiquantitative estimation of the cerebrovascular amyloid-related protein deposition was analyzed using Fisher's exact test. Severe amyloid β-protein (p<0.013) and apolipoprotein E (p<0.013) immunoreactivity were risk factors for the occurrence of the hemorrhage. Severe cystatin C immunoreactivity was a risk factor for the occurrence (p<0.002) and enlargement (p<0.014) of the hemorrhage, and tended to induce recurrent hemorrhage (p<0.103). In addition, loss of the vascular smooth muscle was observed in the intensely amyloid-laden vascular walls that showed cystatin C-immunoreactivity. The present study indicates that intense amyloid β-protein deposition with cystatin C deposition weakens the cerebrovascular walls, and that cystatin C deposition is a strong predictor of hemorrhage in cerebral amyloid angiopathy.
- 日本脳神経外科学会の論文
- 2001-10-15
著者
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Ito Haruhide
Department Of Neurosurgery And Neurology Yamaguchi University School Of Medicine
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Hoshii Yoshinobu
First Department Of Pathology Yamaguchi University Graduate School Of Medicine
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Ishihara Tokuhiro
First Department Of Pathology Yamagata University School Of Medicine
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Izumihara Akifumi
Department Of Neurosurgery Yaeyama Prefectural Hospital
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Izumihara Akifumi
Department Of Neurosurgery Shuto General Hospital
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Ito Haruhide
Department Of Neurosurgery Yamaguchi Rosai Hospital
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