血脳関門破壊時と glucocorticoid による修復時のカテコラミン動態に関する蛍光顕微鏡的研究

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Histochemical examinations of the cerebral cortex of rats were performed using the Falck-Hillarp method,to observe an enzymatic blood-brain barrier mechanism of intracerebral capillary endothelitum and a repair-mechanism of damaged blood-brain barrier with glucocorticoids.After depletion of the endogenous monoamines with a large dose of reserpine, dopamine and trypan blue were given intraperitoneally to the three groups of rats ; control group, cold injury group, and cold injury group treated with dexamethazone.In the control group, dopamine and trypan blue rernained in the capillary lumen and had no penetration into the cerebral parenchyma.In the cold injury group, dopamine and trypan blue penetrated into cerebral parenchyma freely through the endothelium in the edematous regions. Dopamine was uptaken into neurons and astrocytes, and trypan blue penetrated into neuropil in the edematous regions.In the cold injury group treated with dexamethazone, dopamine was uptaken into the capillary endothelium in the edematous regions. Trypan blue was not found in the capillary endothelium.From these findings, it is concluded that the capillary endothelium loses an enzymatic: barrier rnechanism by the cold injury,but that dexamethazone restores the protective function of the capillary endothelium to dopamine-penetration into the cerebral parenchyma. It is suggested that dexamethazone activates an etnzymatic reaction in the endothelium or produces a structural repair of the endothelial basement menbranes and astrocytic feet.
日本脳神経外科学会の論文
1978-12-15

血脳関門破壊時と glucocorticoid による修復時のカテコラミン動態に関する蛍光顕微鏡的研究

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