Increased expression of deoxyribonucleic acid methyltransferase gene in human astrocytic tumors
スポンサーリンク
概要
- 論文の詳細を見る
The relationship between the grade of astrocytic tumor and the expression of deoxyribonucleic acid methyltransferase (DNA-MTase) gene was examined. The levels of DNA-MTase messenger ribonucleic acid (mRNA) were measured by semiquantitative reverse transcriptase-polymerase chain reaction in surgical specimens from 12 astrocytic tumors (4 astrocytomas, 6 anaplastic astrocytomas, and 2 glioblastomas) and two normal brain tissues, and in four glioma cell lines. Compared to normal brain tissues, the levels of DNA-MTase mRNA were increased by 16- to 55-fold in low grade astrocytomas, and significantly increased by 200- to 4500-fold in high grade astrocytomas (anaplastic astrocytomas and glioblastomas) and more than 4500-fold in glioma cell lines. In situ hybridization with paraffin-embedded surgical specimens of human astrocytic tumors showed DNA-MTase mRNA was abundantly expressed in high grade astrocytomas. The detection of increased DNA-MTase expression in astrocytic tumor indicates involvement in the tumorigenesis and suggests that blocking of this change with specific inhibitors may offer new therapeutic strategies for malignant astrocytic tumors.
- 日本脳神経外科学会の論文
- 2000-11-15
著者
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HAYASHI Yutaka
Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University
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Okada Takashi
Department of Cardiology, Kyoto First Red Cross Hospital
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YAMASHITA Junkoh
Department of Neurosurgery, Division of Neuroscience, Graduate School of Medical Science, Kanazawa U
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Okada Takashi
Department Of Cardiology Kyoto First Red Cross Hospital
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Yamashita Junkoh
Department Of Neurosurgery
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OKADA Yoshie
Department of Neurosurgery
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NUMATA Masayuki
Anatomy, Kanazawa University School Medicine
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YAMASHITA Tetsumori
Department of Neurosurgery
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Numata Masayuki
Anatomy Kanazawa University School Medicine
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Yamashima Tetsumori
Department Of Neurosurgery Kanazawa University School Of Medicine
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Okada Takashi
Department Of Neurosurgery
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Hayashi Yutaka
Department Of Cardiology Uwajima Social Insurance Hospital
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Nomura Masayuki
Anatomy, Kanazawa University School Medicine
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Yamashima Tetsumori
Department of Neurosurgery
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