Medulloblastomaの異種移植 : 特に神経病理学的分類への応用を中心として
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Human medulloblastomas obtained from 6 children were heterologously transplanted into the brains of Hy-3 strain mice with and without anti-thymocyte serum (ATS) treatment. Mice were sacrified 3 months after the inoculation of tumors. Active tumor growths were observed only in 7 out of 29 ATS treated mice (24%) while no tumor-growth was seen in the controls. Tumor growths were always situated in the areas adjacent to the lateral ventricle or in the subarachnoid space. The histological pictures of these tumors were essentially similar to those of original tumors. Transplanted tumors were composed of two main tissue architectures. The major part of the tumor was composed of typical medulloblastoma cells with mitotic figures and pseudoresette formations, and there were scattered areas of the so-called "pale islands." Tumor cells surrounding the "pale islands," however, did not show any specific patterns, such as trabecular arrangement of neoplastic cells which was observed in. original tumors. Fibrous tissue around "pale islands" were much less than those seen in original tumors. The electron microscopic study revealed that glial fibrils were present in the processes of the tumor cells and that many unmyelinated axons were encountered among the tumor cells. The following might be concluded from the present study: 1) tumor growth may be promoted either directly or indirectly by the presence of CSF and presumably of choroid plexus; 2) fibrous areas of "pale island" seems to be reactive changes of the leptomeninges to the encroaching tumor since these findings disappeared completely in the transplanted tumors, though pale islands did exist. From this finding so-called "arachnoidal cerebellar sarcoma" is thought to be classified as one form of medulloblastoma modified by the interaction between medulloblastoma cells and fibrous tissue from arachnoid membrane; 3) medulloblastoma cells might have bipontentiality in differentiating toward either neurons or glial cells; and 4) it should be stressed that the heterologous transplantation of tumors could be a useful tool for the resolution of certain neuropathological problems.
- 日本脳神経外科学会の論文
- 1979-10-15
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