Effect of Local Administration of Lymphokine-activated Killer Cells and Interleukin-2 on Malignant Brain Tumor Patients
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概要
- 論文の詳細を見る
Nine patients with malignant brain tumors were treated with intratumoral infusion of lymphokine-activated killer (LAK) cells and interleukin-2 (IL-2). LAK cells were generated from macrophage-depleted peripheral blood lymphocytes by culturing with IL-2 for 4 days. The resulting LAK cells showed strong cytotoxic activity against tumor target cells. Three patients received sufficient LAK cells (≧5.76×10^8) to show partial tumor response by computed tomography and clinical signs. No severe neurological side effects occurred in any patient. Intratumoral administration of LAK cells and IL-2 can be effective in patients with malignant brain tumors.
- 日本脳神経外科学会の論文
- 1993-07-15
著者
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八巻 稔明
札幌医科大学付属病院脳神経外科
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UEDE Teiji
Department of Neurosurgery, Sapporo Medical University
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HASHI Kazuo
Department of Neurosurgery,Osaka City University Medical School
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KUBOTA Tsukasa
Departments of Neurosurgery, Kushiro Neurosurgical Hospital
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YAMAKI Toshiaki
Department of Neurosurgery, Sapporo Medical University School of Medicine
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Yamaki Toshiaki
Department Of Neurosurgery Sapporo Medical University School Of Medicine
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Uede Teiji
Department Of Neurosurgery Sapporo Medical College
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Uede Teiji
Department Of Neurosurgery Kushiro City General Hospital
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Hashi Kazuo
Department Of Neurosurgery Osaka City University Medical School
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Kubota Tsukasa
Department Of Neurosurgery Sapporo Medical College
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IBAYASHI Yukihiro
Department of Neurosurgery, Sapporo Cancer Center
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TANABE Sumiyoshi
Department of Neurosurgery, Sapporo Medical University School of Medicine
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KAWAHARA Takahisa
Department of Neurosurgery, Sapporo Medical College
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DAIBO Masahiko
Department of Neurosurgery, Sapporo Medical College
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Daibo Masahiko
Department Of Neurosurgery Sapporo Medical College
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Tanabe Sumiyoshi
Department Of Neurosurgery Sapporo Medical University School Of Medicine
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Kawahara Takahisa
Department Of Neurosurgery Sapporo Medical College
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Ibayashi Yukihiro
Department Of Neurosurgery Sapporo Medical University School Of Medicine
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Ibayashi Yukihiro
Department Of Neurosurgery Sapporo Cancer Center
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HASHI Kazuo
Department of Neurosurgery, Sapporo Medical University School of Medicine
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