Reduction of glycolipids with D-PDMP, a glucosylceramide synthetase inhibitor, caused cell growth inhibition, enhanced cell adhesion, and facilitated cell motility in human glioma cells

スポンサーリンク

概要

• 論文の詳細を見る

• Glycolipid synthesis inhibitor, D-PDMP, not only inhibited the production of glycolipid but also inhibited cell growth in human glioma cell line KG-1C in a cell cycle non-dependent manner. The reduction of glycolipid from the cell membrane allowed us to study the biological functions of glycolipids. The ability of cells to adhere to collagen was enhanced by the reduction of glycoli-pids, and random cell migration was also activated by the effect of D-PDMP. The results supported our speculation that glycolipids might function in cell growth, adherence and locomotion.

• 札幌医科大学の論文

著者

• Yamaki Toshiaki

  Department Of Neurosurgery Sapporo Medical University School Of Medicine

• Piao Haozhe

  Department of Neurosurgery, Sapporo Medical University School of Medicine

• Yu Hongwei

  Department of Neurosurgery, Sapporo Medical University School of Medicine

関連論文

• Development of a New Inhibitor of Glucosylceramide Synthase^1
• Supratentorial Glioma Manifesting as Acute Onset of Pure Motor Hemiparesis : Case Report
• Treatment of Multiple Intracranial Aneurysms in the Anterior Circulation : Case Report
• Effect of Local Administration of Lymphokine-activated Killer Cells and Interleukin-2 on Malignant Brain Tumor Patients
• Interleukin 4 Enhances Ganglioside GD3 Expression on the Human Fibroblast Cell Line WI-38
• Feeding Arteries of Parasellar Meningiomas : Angiographic Study of Medial Sphenoid Ridge and Tuberculum Sellae Meningiomas
• Metastatic Renal Cell Carcinoma Mimicking Pituitary Adenoma
• Reduction of glycolipids with D-PDMP, a glucosylceramide synthetase inhibitor, caused cell growth inhibition, enhanced cell adhesion, and facilitated cell motility in human glioma cells

スポンサーリンク