Effect of Combined Treatment with Magnetic Induction Hyperthermia and Chemotherapy in a Rabbit Brain Tumor Model
スポンサーリンク
概要
- 論文の詳細を見る
The effects of interstitial magnetic induction hyperthermia alone and in combination with chemotherapy were evaluated in a rabbit brain tumor model. VX2 carcinoma cells were implanted intracerebrally in 28 rabbits. The animals were divided into four groups of seven each, and the experimental protocols were started on the 7th day after inoculation. Group 1 underwent hyperthermia alone by means of implantation of a needle (Fe-Pt alloy) in the tumor, which was maintained at 45℃ for 30 minutes. Group 2 received 12.5 mg/kg ACNU intravenously via a lateral ear vein. In Group 3, 10 minutes after injection of ACNU, hyperthermia was induced in the same manner as in Group 1. Group 4 were controls and received no treatment. The four groups were evaluated and compared in terms of length of survival and pathological features of their brain tumors at the time of death. The mean survival times of Groups 1, 2, 3, and 4 were 14.7, 14.7, 17.3, and 12.3 days, respectively. Statistically significant differences were found between Groups 1 and 4 and between Groups 3 and 4, but not between Groups 1 and 2. Pathological findings in the hyperthermia gfoup included necrosis around the implant. The tumor cells surrounding the necrotic area had degenerated and the vessels were dilated and static. Thus, in this rabbit brain tumor model, hyperthermia alone was significantly superior to no treatment, and combined treatment with hyperthermia and chemotherapy was more effective than either treatment alone.
- 日本脳神経外科学会の論文
- 1989-05-15
著者
-
Takahashi Tatsuo
Department Of Surgery Keio University School Of Medicine
-
Hattori Kazuyoshi
Department Of Neurosurgery Nagoya University School Of Medicine
-
Tanaka Takayuki
Department Of Engineering Systems And Technology Graduate School Of Science And Engineering Saga Uni
-
Kobayashi Tatsuya
Department Of Applied Chemistry Graduate School Of Engineering Nagoya University
-
Tanaka Takayuki
Department Of Applied Physics Fukuoka University
-
Tanaka Takayuki
Department Of Neurosurgery Nagoya University School Of Medicine
-
Takahashi Tatsuo
Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University
-
KOBAYASHI Tatsuya
Department of Neurosurgery, Nagoya University School of Medicine
関連論文
- Prognostic factors for survival and bladder recurrence in transitional cell carcinoma of the upper urinary tract
- Multiple Variant mRNAs with Different Length Tandem Repeats of (CAYYCC)n Produced from Bovine Selenoprotein P-like Protein Gene
- Preclinical Cushing's syndrome: Report of seven cases and a review of the literature
- Incidentally discovered pheochromocytoma in long-term hemodialysis patients
- Primary Aldosteronism due to Unilateral Adrenal Hyperplasia: Report of Two Cases and Review of the Literature
- Aldosterone-Producing Adrenal Cortical Cancer : A Case Report and Analysis of Steroidogenic Enzymes in the Tumor
- Second Transplantation from HLA 2-Loci-Mismatched Mother for Graft Failure Due to Hemophagocytic Syndrome after Cord Blood Transplantation
- Examination of mitral valve repair with port-access method : Aiming at early and less invasive mitral valve repair
- Bony lnvasion of lntracranial Meningioma with Remarks to Recurrences
- Angiographically Occult Arteriovenous Malformation in the Septal Region : Case Report
- Annual Variations of the Elemental Concentrations of PM_ in Ambient Air of Nagoya City as Determined by ICP-AES and ICP-MS
- Chemical Characterization of Airborne Particulate Matter in Ambient Air of Nagoya, Japan, as Studied by the Multielement Determination with ICP-AES and ICP-MS
- Successful Treatment of Dwarfism and Hypogonadism after Total Removal of Craniopharyngioma
- Multimodality Treatment of Malignant Glioma : Effect of Chemotherapy with ACNU and Immunotherapy with N-CWS
- Pathological and Clinical Basis of the Indications for Treatment of Craniopharyngiomas
- Subarachnoid Hemorrhage of Unknown Origin Associated with Weber-Christian Disease : Case Report
- Connective tissue growth factor mediates the profibrotic effects of transforming growth factor-β produced by tubular epithelial cells in response to high glucose
- Inhibitory mechanisms of flavonoids on insulin-stimulated glucose uptake in MC3T3-G2/PA6 adipose cells
- Intracellular Localization and Partial Amino Acid Sequence of a Stress-Inducible 40-kDa Protein in HeLa Cells
- Effect of Cisternal Papaverine on Cerebral Blood Flow in Patients with Subarachnoid Hemorrhage : Three Case Reports
- Advanced Utilization of Microwave Resonant Fields and Its Applications to Push-Push Oscillators and Reconfigurable Antennas(Emerging Microwave Techniques)
- Effect of Glycerol on Blood Flow Distribution in Tumoral and Peritumoral Brain Tissue
- Aortic Root Re-replacement with Cryopreserved Aortic Homograft in a Patient with Active Composite Valve-graft Endocarditis
- Extensive total arch replacement via clamshell incision in a patient with aortic arch aneurysm and Stanford type B aortic dissection
- Early Changes in Volume and Non-enhanced Volume of Acoustic Neurinoma after Stereotactic Gamma-radiosurgery
- Incidental White Matter Lesions Identified on Magnetic Resonance Images of Normal Japanese Individuals : Correlation with Age and Hypertension
- Imagings of Picosecond-Photoexcited Carriers and Enhanced Auger Recombination Rate by Transient Reflecting Grating Measurements
- Laser-Stimulated Scattering Microscope Study of an Jon-Implanted Silicon Surface
- The 8th Harmonic Push-Push Oscillator in V Band
- Gastrointestinal Cancer Metastasis and Lymphatic Advancement
- Magnetic Resonance Angiography of Arteriovenous Malformation in the Thalamus
- Magnetic Resonance Angiography of Arteriovenous Malformation in the Brainstem
- The Utility of Formalin-fixed and Paraffin-embedded Tissue Blocks for Quantitative Analysis of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase mRNA Expressed by Colorectal Cancer Cells
- A Heuristic Molecular-Dynamics Approach for the Prediction of a Molecular Crystal Structure
- Involvement of Subarachnoid Space by Tumor Cells Injected into Peripheral Nerve : An Experimental Study
- Basal Meningioma. Diagnostic and Therapeutic Considerations
- Notch on the T Wave
- Spatiotemporal Dynamics in a Linear Array of Coupled Coherence Resonance Oscillators(Oscillation, Chaos and Network Dynamics in Nonlinear Science)
- Arteriovenous Malformation Associated with Moyamoya Disease : Case Report
- PERIPHERAL NEURAL CIRCUIT IN THE FOOT OF GASTROPOD, PLEUROBRANCHAEA(Physiology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- Low Noise Second Harmonic Oscillator Using Mutually Synchronized Gunn Diodes
- K-Band Second Harmonic Oscillator Using Mutually Synchronized Gunn Diodes Embedded on Slot Line Resonators
- Basic Behavior of Quadruple-Push Oscillator Using Ring Resonator(Microwaves, Millimeter-Waves)
- A 20GHz Push-Push Oscillator Using Ring Resonator(Microwaves, Millimeter-Waves)
- A K-band Push-Push Oscillator Using λ_g/2 Microstrip Resonator(Special Issue on Microwave and Millimeter Wave Technology)
- Effect of Combined Treatment with Magnetic Induction Hyperthermia and Chemotherapy in a Rabbit Brain Tumor Model
- Ferrocene-appended Subporphyrins
- Recanalization of the Lymph Vessels After a Division of the Intestinal Lymph Trunk in the Rat
- A K-band Push-Push Oscillator with High Suppression of Undesired Harmonic Signals(Special Issue on Microwave and Millimeter Wave Technology)
- Subporphyrins : A Legitimate Ring-Contracted Porphyrin with Versatile Electronic and Optical Properties
- Unmanned Production Based on Cooperation between Off-line Robots and On-line Robots
- "Physiological" Age as an Outcome Predictor for Abdominal Surgery in Elderly Patients
- Successful bone reconstruction after bortezomib therapy in a myeloma patient
- Petrological and Geochemical Characteristics of Intrusive Rocks Related to Porphyry Copper Mineralization and the Implications for the Genesis of Deposits in the Namosi area, Viti Levu, Republic of the Fiji Islands
- Tetrandrine Prevents Bone Loss in Sciatic-Neurectomized Mice and Inhibits Receptor Activator of Nuclear Factor κB Ligand-Induced Osteoclast Differentiation
- CD5-Negative Mantle Cell Lymphoma Resembling Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue : A Case Report
- Two Fermi Surface States and Two T_{\text{c}}-Rising Mechanisms Revealed by Transport Properties in RFeP
- Imagings of Picosecond-Photoexcited Carriers and Enhanced Auger Recombination Rate by Transient Reflecting Grating Measurements
- Two Fermi Surface States and Two Tc-Rising Mechanisms Revealed by Transport Properties in RFeP₁₋xAs[x]O₀.₉F₀.₁ (R = La, Pr, and Nd)