Changes in Lumped and Rate Constants in Experimental Cerebral Ischemia : Intra-animal Comparison before and after Middle Cerebral Artery Occlusion

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概要

• 論文の詳細を見る

• Changes in the lumped and transfer rate constants for 2-[^<18>F]fluoro-2-deoxy-D-glucose (2-[^<18>F]FDG) were studied before and 16 hours after bilateral middIe cerebral artery (MCA) occlusion in four cats. The time course of cerebral tissue radioactivity [C^*_i(t)] in a volume of brain was monitored by external coincidence counting during a programmed infusion of 2-[^<18>F]FDG. The arterial plasma concentration [C^*_p(t)] of the tracer was kept constant during the first 45 minutes. The apparent rate constants were estimated from the C^*_i(t) and C^*_p(t) by a weighted, nonlinear least squares fitting method. The lumped constant (LC) was estimated from the fit of the ratio of extraction fractions of glucose and 2-[^<18>F]FDG by a nonweighted, nonlinear least squares fitting. At 16 hours after MCA occlusion, the k^*_1 was 39% lower, the k^*_2 19% 1ower, the k^*_3 27% lower, and the LC 74% higher relative to the preocclusion values. A 65% reduction in gIucose utilization was also observed.

• 日本脳神経外科学会の論文
• 1988-01-15

著者

• Diksic Mirko

  Cone Neurosurgical Research Laboratory And Neuroisotope Laboratory Montreal Neurological Institute M

• NAKAI Hirofumi

  Cone Neurosurgical Research Laboratory and Neuroisotope Laboratory, Montreal Neurological Institute,

• MATSUDA Hiroshi

  Cone Neurosurgical Research Laboratory and Neuroisotope Laboratory, Montreal Neurological Institute,

• TAKARA Eiichi

  Cone Neurosurgical Research Laboratory and Neuroisotope Laboratory, Montreal Neurological Institute,

• YAMAMOTO Yasokazu

  Cone Neurosurgical Research Laboratory and Neuroisotope Laboratory, Montreal Neurological Institute,

• MEYER Ernst

  Cone Neurosurgical Research Laboratory and Neuroisotope Laboratory, Montreal Neurological Institute,

• REDIES Christoph

  Cone Neurosurgical Research Laboratory and Neuroisotope Laboratory, Montreal Neurological Institute,

• Meyer Ernst

  Cone Neurosurgical Research Laboratory And Neuroisotope Laboratory Montreal Neurological Institute M

• Takara Eiichi

  Cone Neurosurgical Research Laboratory And Neuroisotope Laboratory Montreal Neurological Institute M

• Nakai Hirofumi

  Cone Neurosurgical Research Laboratory And Neuroisotope Laboratory Montreal Neurological Institute M

• Redies Christoph

  Cone Neurosurgical Research Laboratory And Neuroisotope Laboratory Montreal Neurological Institute M

• Yamamoto Yasokazu

  Cone Neurosurgical Research Laboratory And Neuroisotope Laboratory Montreal Neurological Institute M

• Matsuda Hiroshi

  Cone Neurosurgical Research Laboratory And Neuroisotope Laboratory Montreal Neurological Institute M

関連論文

• Changes in Lumped and Rate Constants in Experimental Cerebral Ischemia : Intra-animal Comparison before and after Middle Cerebral Artery Occlusion
• Concomitant in Vivo Measurement of Lumped and Rate Constants for F18 FDG in Cat Brain

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