Concomitant in Vivo Measurement of Lumped and Rate Constants for F18 FDG in Cat Brain
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概要
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External coincidence counting was used for simultaneous estimation, in the 2-fluoro-2-deoxy-D-glucose (2-FDG) model, of the lumped and apparent rate constants (i.e., for a white/gray matter mixture). Eleven normal cats were studied. During a programmed 2-[^<18>F]FDG infusion that kept a constant arterial plasma concentration of 2-[^<18>F]FDG [C^*_p(t)] for 45 minutes, the time course of cerebral tissue activity [C^*_i(t)] was monitored by external coincidence counting. The apparent rate constants were estimated from C^*_i(t) and C^*_p(t) by a nonlinear least squares optimization method. The lumped constant (LC) estimate was obtained by fitting the ratio of extraction fractions of glucose and 2-[^<18>F]FDG by use of a nonweighted, nonlinear least squares fitting method. The estimated apparent rate constants, k^*_1, k^*_2, k^*_3, and the LC were O.074±O.005 min^<-1>, O.129±0.007 min^<-1>,0.021±0.001 min^<-1>, and 0.395±0.016, respectively (mean±SEM). The focal cerebral metabolic rate for glucose detected in the brain was 28.7±1.5 μmol/100gm/min (mean±SEM). The influence of arterial plasma glucose (C_p), the LC, and the metabolic index [MI = k^*_1k^*_3}/(k^*_2+ k^*_3)] on the stability of the cerebral glucose utilization rate was examined. Negative correlations between C_p and LC, and C_p and MI were observed. However, there was a positive correlation between the LC and the MI. The method applied in this study should be very useful in the detection of changes in the kinetics of 2-[^<18>F]FDG under pathophysiological conditions in animals. Because of the short half-life of this isotope, repeated measurements are possible.
- 日本脳神経外科学会の論文
- 1988-01-15
著者
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Diksic Mirko
Cone Neurosurgical Research Laboratory And Neuroisotope Laboratory Montreal Neurological Institute M
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NAKAI Hirofumi
Cone Neurosurgical Research Laboratory and Neuroisotope Laboratory, Montreal Neurological Institute,
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MATSUDA Hiroshi
Cone Neurosurgical Research Laboratory and Neuroisotope Laboratory, Montreal Neurological Institute,
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TAKARA Eiichi
Cone Neurosurgical Research Laboratory and Neuroisotope Laboratory, Montreal Neurological Institute,
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YAMAMOTO Yasokazu
Cone Neurosurgical Research Laboratory and Neuroisotope Laboratory, Montreal Neurological Institute,
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MEYER Ernst
Cone Neurosurgical Research Laboratory and Neuroisotope Laboratory, Montreal Neurological Institute,
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REDIES Christoph
Cone Neurosurgical Research Laboratory and Neuroisotope Laboratory, Montreal Neurological Institute,
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KIRIKAE Michihiro
Cone Neurosurgical Research Laboratory and Neuroisotope Laboratory, Montreal Neurological Institute,
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Meyer Ernst
Cone Neurosurgical Research Laboratory And Neuroisotope Laboratory Montreal Neurological Institute M
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Takara Eiichi
Cone Neurosurgical Research Laboratory And Neuroisotope Laboratory Montreal Neurological Institute M
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Nakai Hirofumi
Cone Neurosurgical Research Laboratory And Neuroisotope Laboratory Montreal Neurological Institute M
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Redies Christoph
Cone Neurosurgical Research Laboratory And Neuroisotope Laboratory Montreal Neurological Institute M
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Kirikae Michihiro
Cone Neurosurgical Research Laboratory And Neuroisotope Laboratory Montreal Neurological Institute M
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Yamamoto Yasokazu
Cone Neurosurgical Research Laboratory And Neuroisotope Laboratory Montreal Neurological Institute M
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Matsuda Hiroshi
Cone Neurosurgical Research Laboratory And Neuroisotope Laboratory Montreal Neurological Institute M
関連論文
- Changes in Lumped and Rate Constants in Experimental Cerebral Ischemia : Intra-animal Comparison before and after Middle Cerebral Artery Occlusion
- Concomitant in Vivo Measurement of Lumped and Rate Constants for F18 FDG in Cat Brain