光線力学的治療が子宮頸部上皮内腫瘍のHPV感染に及ぼす影響

概要

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We treated 14 patients with cervical intraepithelial neoplasia (CIN) by photodynamic therapy (PDT) by using polyhematoporphyrin ether/ester (PHE) and assessed the effectiveness of PDT colposcopically, cytologically, and histologically. Detection and typing of human papillomavirus (HPV) in the cervical lesions was also performed by PCR with L1 consensus primers before and 3 months after PDT. Sixty hours prior to PDT, 2mg/kg of PHE was administered and PDT was performed with an YAG-OPO laser at 630nm. Local toxity was minimal and no systemic effects were seen. After 3 months of follow-up, colposcopic grading characteristics of the lesions as well as exofelitative cytology and/or directed biopsy revealed regression of the disease in all 14 patients. HPV-DNA was detected in all 14 CIN lesions before PDT. Three months after PDT, however, HPV-DNA was not found in the cervixes of these patients. These preliminary results suggest that PDT with PHE and YAG-OPO laser at 630 nm is safe and effective not only in improving the pathological findings but also in eradicating cervical HPV in treating CIN.
社団法人日本産科婦人科学会の論文
2001-08-01