先天性胆道拡張症における肝障害の病理組織学的検討

概要

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In 32 patients with congenital dilatation of the bile duct, biopsy specimens of liver tissue at operations were analized histopathologically. Sixteen patients with jaundice were compaired with 16 without jaundice. Abnormal chenges of liver tissue were found in 69% of cases with jaundice and 44% of cases without jaundice. Liver cirrhosis were shown in 2 cases with jaundice and 1 case without jaundice. Incidence of abnormal change of liver tissue was high in cases with jaundice than in those without jaundice. Cases without jaundice exhibited more than slight changs of liver tissue. Liver damage was thought to be induced not only by obstruction of the bile duct but also by activated pancreatic enzymes regurgitating into the bile duct through anomalous junctions of the pancreatico-biliary ductal system.
日本小児外科学会の論文
1992-12-20