Teratoid Type Hepatoblastomaの1例

概要

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The presence of mesenchymal tissue, such as bone or cartilage in the hepatoblastoma, is a well recognized occurrence. However, multiple lines of tissue differentiation in a hepatoblastoma have rarely been observed. Such case of so-called teratoid type hepatoblastoma is presented. A 3-year-old Japanese girl was admitted to Osaka University Hospital with a right upper abdominal mass. Serum α-fetoprotein level was remarkably elevated (208000ng/ml). NSE and CEA was slightly elevated. The tumor lesion occupied the right lobe of the liver. Extended right lobectomy was performed. The tumor was 12×10×9 cm in size, and consisted of multiple nodules. Post-operative chemotherapy was performed for one year. The patient is alive 5 years after the operation with good health. In this tumor, most lesion consisted of fetal type hepatoblastoma, but there were some areas showing embryonal hepatoblastoma. Furthermore, various component of tridermic tissues such as immature neural tissue, keratoid tissue, melanin producing cells, caltilage. bone, striated muscle, glands, and columnar epithelium were found in the tumor tissue. Immunohis-tochemical studies confirmed various differentiation of tumor cells into tridermic tissue and histological diagnosis was made as a teratoid type hepatoblastoma.
日本小児外科学会の論文
1992-08-20