卵巣癌化学療法後に発症した二次性白血病の1例

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A27-year-old woman with stage IIc clear cell overian adenocarcinoma underwent cytoreductive surgery and received the following postoperative chemotherapy : intraperitoneal infusion of 50 mg/m^2 cisplatin plus 350 mg/m^2 fuorouracil twice and 6 cycles of systemic chemotherapy consisting of 400 mg/m^2 cyclophosphamide, 30 mg/m^2 doxorubicin and 50 mg/m^2 cisplatin. Three years after the chemotherapy, the white blood-cell count had increased to 14,000/μ1(blast 78.5%). Bone marrow aspiration showed monotonous blast proliferation. Cytochemical findings and immunophenotype were consistent with acute myeloid leukemia (AML). Cytogenetic analysis revealed abnormal clones with 46, XX, t(9 ; 11) (p22 ; q23). In view of these findings, it was suggested that secondary AML was induced by doxorubicin, topoisomerase II inhibitor forovarian cancer chemotherapy.
社団法人日本産科婦人科学会の論文
1999-02-01