画像診断法による神経芽腫骨転移の解析

概要

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Twenty five patients with advanced neuroblastoma were shown to have bone matastasis with skeletal X-rays and/or bone scanning. The characteristic skeletal abnormalities in the metastatic neuroblastoma are a lytic-permiating lesion and periosteal reactions (single-layered or multilayered periosteal reaction or sunburst) on the radiograph. The most common bones of metastasis in neuroblastoma are the femur and skull. Sixteen patients with skeletal metastasis of neuroblastoma were examined in the distal femurs and proximal tibiae with magnetic resonance imaging (MRI). Metastatic lesions appeared of high intensity on T2 weighted (SE 1,500/60). Small lesions which had not been shown with bone scanning were found by MRI. It is likely these small lesions might be early metastasis of neuroblastoma to the distal femurs via hematogeneous spread. Bone-marrow involvement was also seen as areas of high intensity. MRI appears to be valuable for the staging and followup of children with neuroblastoma.
特定非営利活動法人日本小児外科学会の論文
1988-10-20