進行神経芽細胞腫におけるcis-Diamminedichloroplatinum (II) 投与時の腎機能検査に関する検討

概要

論文の詳細を見る
BUN, serum creatinine, creatinine clearance, fractional excretion of sodium (FENa), serum β_2-microglobulin, urinary β2-microglobulin, and urinary N-acetyl-β-D-glucosaminidase (NAG) were measured in eight patients with advanced neuroblastoma who were receiving cis-diammine-dichloroplatinum (II) (CDDP). These parameters changed within the first week after CDDP treatment. Increased urinary excretion of NAG was observed untill the second week had passed after CDDP administration. But the value of each parameter on the 3rd day after CDDP administration was not significantly correlated with the cummulated dose of CDDP administered. These results indicate that these parameters show acute renal injury due to CDDP treatment, but the long-term latent nephrotoxicity of CDDP cannot be predicted from these parameters.
日本小児外科学会の論文
1987-12-20