HBs 抗原陽性小児肝癌について : 自験2例と文献的考察

概要

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Two 8-year-old boys having hepatocellular carcinoma (liver-cell carcinoma, adult type) associated with hepatitis B surface antigen (HBs-Ag) positive were reported and discussed with 5 cases in Japan riviewed in the literature. The first patient was HBs-Ag positive in serological examination. He was suspected to be a case of maternal (vertical) transmission, because he was pointed out as suffering from hepatomegaly at the age of three months and his mother was an HBs-Ag positive carrier. The second case had not undergone serological examination but histologically Orsein-stainpositive cells were present in non-neoplastic liver tissues at autopsy. He also had liver cirrhosis type B. HB virus infection, because of maternal transmission or horizontal tansmission in children less than 4 years of age, results in HBs-Ag positive carrier, chronic hepatitis and liver cirrhosis type B. These hepatocellular carcinomas associated with HBs-Ag positive demonstrate that HB virus infection will cause hepatocellular carcinoma not only in children as well.
1984-10-20