遊泳運動が絶食時のラット肝triglyceride蓄積におよぼす影響

概要

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The present study was carried out to elucidete whether the accumulation of triglyceride (TG) in rat liver during fasting was stimulated by swimming. Male Wistar rats were divided into three groups ; C : control, 24 F : 24 hour-fasted and 48 F : 48 hour-fasted. These animals were required to swim for 120 min. In rats with both 24 F and 48 F, the liver glycogen contents did not change during swimming. The level of TG in rat liver was higher in 24 F and 48 F rats than the control group, and the exercise significantly affected the liver TG in each group. There was significant correlation betweem the level of TG in rat liver and the plasma free fatty acid (FFA) concentration (r=0.681,p<0.01). However, although plasma TG did no change during exercise in each group, the TG secretion rate (TGSR) of the 48 F group was significantly lower than that of the C and 24 F groups (p<0.01). These results provide evidence that exercise may result in the accumulation of TG in liver during fasting and suggest that the process not only depends on the surplus supply of FFA, but also inhibits very low density lipoprotein-TG secretion from liver.
1992-04-01