Multiple Endocrine Neoplasia Type 1: From Bedside to Benchside

スポンサーリンク

概要

• 論文の詳細を見る

• Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized by the combined occurrence of parathyroid, pancreatic endocrine, and anterior pituitary tumors. MEN1 has two characteristics ; a hormone excess and a sometimes lethal outcome due to malignant tumors. The recent identification of the MEN1 gene has opened the door to a much deeper understanding of this syndrome. Germline MEN1 mutations have been identified in most MEN1 families. They were not found, however, in families with familial pituitary tumors. Thus, studies with the MEN1 gene helped to establish that mutation of some other gene(s) is likely causative of the MEN1 phenocopy. These recent advances provide for the identification of mutant MEN1 gene carriers who are at a high risk of developing MEN1. The protein encoded by the MEN1 gene has been shown to function in the regulation of JunD-activated transcription but much still remains to be elucidated.

• 徳島大学の論文

著者

• Yoshimoto Katsuhiko

  Department Of Pharmacology School Of Dentistry The University Of Tokushima

• Yoshimoto Katsuhiko

  徳島大学医学部

関連論文

• Absence of Mutations at Codon 768 of the RET Proto-Oncogene in Sporadic and Hereditary Pheochromocytomas
• Tumor-Specific Muations in the Tyrosine Kinase Domain of the REN Proto-Oncogene in Pheochromocytomas of Sporadic Type
• Human Pituitary Adenomas Infrequentry Contain Inactivation of Retinoblastoma 1 Gene and Activation of Cyclin Dependent Kinase 4 Gene
• Infrequent Detectable Somatic Mutations of the RET and Glial Cell Line-derived Neurotrophic Factor (GDNF) Genes in Human Pituitary Adenomas
• Mutations in the Cysteine-Rich Region of the RET Proto-Oncogene in Patients Diagnosed as Having Sporadic Medullary Thyroid Carcinoma
• The Rate of Cell Growth Is Regulated by Purine Biosynthesis via ATP Production and G1 to S Phase Transition
• Two Different Pituitary Adenomas in a Patient with Multiple Endocrine Neoplasia Type 1 Associated with Growth Hormone-Releasing Hormone-Producing Pancreatic Tumor: Clinical and Genetic Features
• p53 gene mutation analysis in porokeratosis and porokeratosis-associated squamous cell carcinoma
• Multiple Endocrine Neoplasia Type 1: From Bedside to Benchside

スポンサーリンク